ozi

Ka ọ dị ugbu a, imaging resonance magnet (MRI) na-etolite site na onyonyo nhazi ọdịnala na onyonyo arụ ọrụ gaa na onyonyo molekụla. Multi-nuklia MR nwere ike nweta a dịgasị iche iche nke metabolite ozi n'ime ahụ mmadụ, mgbe ịnọgide na-enwe ohere ohere mkpebi, melite specificity nke nchọpụta nke physiological na pathological usoro, na ugbu a bụ naanị nkà na ụzụ na ike na-abụghị invasive quantitative analysis nke mmadụ ike molekul metabolism na vivo.

Na omimi nke multi-core MR Research, ọ nwere atụmanya ngwa ngwa na nyocha mmalite na nyocha nke etuto ahụ, ọrịa obi, ọrịa neurodegenerative, usoro endocrine, usoro nri digestive na ọrịa iku ume, na nyocha ngwa ngwa nke usoro ọgwụgwọ. Ikpo okwu nyocha ọtụtụ isi nke Philips ọhụrụ ga-enyere aka ịse foto na ndị dọkịta na-ahụ maka ahụike ime nyocha ụlọ ọgwụ dị oke egwu. Dr. Sun Peng na Dr. Wang Jiazheng si Philips Clinical na Nka na ụzụ Nkwado Department nyere a zuru ezu iwebata na mbepụ-ọnụ mmepe nke multi-NMR na nnyocha ntụziaka nke Philips 'ọhụrụ multi-isi MR Platform.

Resonance magnetik emeriela ihe nrite Nobel ugboro ise n'akụkọ ihe mere eme ya, n'ofe physics, kemistri, biology, na ọgwụ, wee nweta nnukwu ihe ịga nke ọma na ụkpụrụ physics bụ isi, usoro mkpụrụ ndụ ihe nketa, usoro ihe nrụzi macromolecular biological, na onyonyo ahụike ụlọ ọgwụ. N'ime ha, ihe onyonyo resonance magnet aghọwo otu n'ime teknụzụ nyocha ahụike ahụike kachasị mkpa, nke a na-ejikarị achọpụta ọrịa dị iche iche n'akụkụ dị iche iche nke ahụ mmadụ. Site na mmụba na-aga n'ihu nke mkpa nlekọta ahụike na-aga n'ihu, nnukwu ọchịchọ maka nchọpụta mmalite na nyocha ngwa ngwa ngwa ngwa na-akwalite mmepe nke imaging resonance magnet site na ihe ngosi omenala omenala (T1w, T2w, PDw, wdg), ihe ngosi ọrụ (DWI, PWI, wdg) na imaging molecular (1H MRS Na multi-core MRS/MRI).

Mgbagwoju anya ndabere nke teknụzụ MR dabere na 1H, ihe nlegharị anya, yana mkpakọ mmiri/abụba na-amachi ohere ya dị ka teknụzụ onyonyo molekụla. Naanị ọnụ ọgụgụ dị nta nke ụmụ irighiri ihe (choline, creatine, NAA, wdg) nwere ike ịchọpụta, ọ na-esiri ike ịnweta usoro metabolic na-agbanwe agbanwe. Dabere na a dịgasị iche iche nke nuclides (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), multi-nuklia MR nwere ike nweta a dịgasị iche iche nke metabolite ozi nke ahụ mmadụ, na elu mkpebi na elu kpọmkwem, na ugbu a bụ nanị ndị na-abụghị invasive, radioactivity nke na-adịghị eme ihe ike (stable) (glucose, amino acids, fatty acids - na-adịghị egbu egbu) maka nyocha ọnụọgụ nke usoro metabolic molecular nke mmadụ.

Na-aga n'ihu na-aga n'ihu na magnetik resonance ngwaike usoro, ngwa ngwa usoro usoro (Multi-Band, Spiral) na acceleration algọridim (mmetụta abịakọrọ, mmụta miri emi), multi-core MR Imaging / spectroscopy ji nwayọọ nwayọọ tozuo: (1) a na-atụ anya na ọ ga-aghọ ngwá ọrụ dị mkpa maka ịkpụ-ọnụ molekụla bayoloji, biochemistry na mmadụ nyocha metabolism; (2) Ka ọ na-esi na nchọpụta sayensị na-aga n'ihu na omume ụlọ ọgwụ (ọtụtụ nyocha ụlọ ọgwụ na-adabere na multi-core MR Are na-aga n'ihu, FIG. 1), ọ nwere atụmanya sara mbara na mmalite nyocha na nchọpụta nke ọrịa cancer, ọrịa obi, ọrịa neurodegenerative, digestive na ọrịa iku ume, na nyocha ngwa ngwa ngwa ngwa.

N'ihi ụkpụrụ anụ ahụ dị mgbagwoju anya na ihe isi ike dị elu nke MR Field, multi-core MR abụrụla mpaghara nyocha pụrụ iche nke ụlọ ọrụ nyocha nke injinịa ole na ole. Ọ bụ ezie na multicore MR enweela ọganihu dị ukwuu ka ọtụtụ iri afọ nke mmepe gasịrị, a ka nwere ụkọ data ụlọ ọgwụ zuru oke iji kwalite ubi a iji jeere ndị ọrịa ozi n'ezie.

Dabere na ihe ọhụrụ na-adịgide adịgide n'ọhịa nke MR, Philips mechara mebie ọkpụkpụ mmepe nke multi-core MR wee wepụta usoro nyocha ụlọ ọgwụ ọhụrụ nwere ọtụtụ nuclides na ụlọ ọrụ ahụ. Ikpo okwu bụ naanị sistemụ multi-core n'ụwa iji nweta Asambodo Nkwekọrịta Safety EU (CE) na asambodo US Food and Drug Administration (FDA), na-eme ka ọkwa ngwaahịa zuru oke n'ọtụtụ isi MR Solution: coils FDA kwadoro, mkpuchi usoro zuru oke, yana nrụzi ọkọlọtọ ụlọ ọrụ. Ọ dịghị mkpa ka ndị ọrụ nwee ndị ọkachamara na-ahụ maka physics resonance magnetik, ndị injinia koodu na ndị na-emepụta gradient RF, nke dị mfe karịa spectroscopy/imaging ọdịnala 1H. Mee ka mbelata nke ụgwọ ọrụ MR multi-core, ngbanwe n'efu n'etiti nyocha sayensị na ọnọdụ ụlọ ọgwụ, mgbake na-efu ngwa ngwa, nke mere na ọtụtụ isi MR n'ezie banye n'ụlọ ọgwụ.

Multi-core MR bụ ugbu a isi ntụzịaka nke "Atụmatụ Mmepe Ngwá Ọrụ Ọgwụ Ahụike Afọ ise nke iri na anọ", ma bụrụ isi teknụzụ maka onyonyo ahụike iji mebie usoro a na-eme ma jikọta ya na biomedicine na-egbu egbu. Ndị ọkà mmụta sayensị Philips China, nke na-akwalite site na imeziwanye nyocha sayensị nke ndị ahịa na ike imepụta ihe, mere nyocha usoro na multi-core MR. Dr. Sun Peng, Dr. Wang Jiazheng et al. nke mbụ tụpụtara echiche nke MR-nucleomics na NMR na Biomedicine (top Journal of the First Region of Spectroscopy of Chinese Academy of Sciences), nke nwere ike iji MR dabere na nuclides dị iche iche iji hụ ọrụ dị iche iche nke cell na usoro pathological. Ya mere, enwere ike ime mkpebi zuru oke na nyocha nke ọrịa na ọgwụgwọ [1]. Echiche nke MR Multinucleomics ga-abụ ntụzịaka nke MR Development n'ọdịnihu. Akwụkwọ a bụ nyocha nhazi nke mbụ nke multi-core MR Na ụwa, na-ekpuchi usoro ihe omimi nke multi-core MR, nyocha nke mbụ, mgbanwe ụlọ ọgwụ, mmepe ngwaike, ọganihu algọridim, omume injinia na akụkụ ndị ọzọ (Nyocha 2). N'otu oge ahụ, otu ndị ọkà mmụta sayensị jikọrọ aka na Prọfesọ Song Bin nke Ụlọ Ọgwụ West China iji mechaa nyocha mbụ banyere mgbanwe ahụike nke multi-core MR Na China, nke e bipụtara na akwụkwọ akụkọ Insights into Imaging [2]. Mbipụta nke usoro isiokwu na multicore MR na-egosi na Philips na-ewetara China, ndị ahịa China, na ndị ọrịa China. N'ikwekọ na isi echiche nke "na China, maka China", Philips ga-eji multi-core MR iji kwalite mmepe nke resonance magnetik nke China ma nyere aka na-akpata China ahụike.

Multi-nuklia MRI bụ teknụzụ na-apụta. Site na mmepe nke MR Software na ngwaike, ọtụtụ MRI ka etinyere ya na nyocha ntụgharị asụsụ nke usoro mmadụ. Uru ya pụrụ iche bụ na ọ nwere ike igosipụta usoro metabolic na-arụ ọrụ nke ọma na usoro pathological dị iche iche, si otú a na-enye ohere maka nchọpụta mmalite nke ọrịa, nyocha nrụpụta ọrụ, mkpebi ọgwụgwọ na mmepe ọgwụ. O nwedịrị ike inye aka ịchọpụta usoro ọhụrụ nke pathogenesis.

Iji kwalite mmepe mmepe nke mpaghara a, ọ dị mkpa itinye aka na-arụsi ọrụ ike nke ndị ọkachamara ahụike. Mmepe nke ụlọ ọgwụ nke nyiwe multicore dị oke mkpa, gụnyere iwu nke sistemu ndị bụ isi, nhazi nke teknụzụ, ọnụọgụ na nhazi nke nsonaazụ, nyocha nke nyocha ọhụrụ, njikọta nke ozi metabolic dị iche iche, wdg, na mgbakwunye na mmepe nke nnwale ndị ọzọ na-atụ anya multicenter, iji wee kwalite mgbanwe ụlọ ọgwụ nke teknụzụ multicore MR dị elu. Anyị kwenyesiri ike na MR multi-core ga-enye ọkwa sara mbara maka onyonyo na ndị ọkachamara ahụike iji mee nyocha ụlọ ọgwụ, nsonaazụ ya ga-abara ndị ọrịa uru gburugburu ụwa.